Hypermobility of the superior tibio-fibular joints.

ment of the costochondral junctions and thickening of the wrists and ankles. X-ray shows cupping and widening of the distal ends of long bones. The serum alkaline phosphatase is raised and both calcium and phosphorus are diminished (Back & Cole, 1958; Palmer & Thomas, 1958). Cretinism in which there is stunted growth, delay in closure of the fontanelle, large tongue and umbilical hernia. The serum cholesterol is raised and there is anaemia.